In 1929, Poli began working for the famous Murano glass company, where he quickly established himself as a talented designer. He worked for several other glass companies throughout his career, including Venini and Seguso Vetri d'Arte, where he created innovative and modern designs.
Poli's creations were often characterized by their elegant simplicity and organic forms, which reflected the influence of abstract art and modern sculpture. He was also influenced by the colors and shapes of nature, creating glass pieces reminiscent of shells, corals and precious stones.
Poli won numerous awards for his work, including the Grand Prix at the Exposition Universelle in Paris in 1937. His creations are still highly prized by collectors and art lovers, and are exhibited in museums around the world, such as the Victoria and Albert Museum in London and the Musée des Arts Décoratifs in Paris.